Comparison of the Effects of 2 Frequencies of Application of Photobiomodulation on Facial Rejuvenation: Controlled, Randomized, and Double-Blind Clinical Trial

Researchers wanted to determine the ideal treatment frequency for red light photobiomodulation (PBM) facial rejuvenation. While previous studies showed benefits for skin aging, treatment schedules varied significantly. This study compared applying red light therapy 2 times per week versus 3 times per week.

Study Design

• Randomized, controlled, double-blind clinical trial
• Female participants aged 45–60 years
• LED facial mask using 660 nm red light
• One group received treatment twice weekly
• Another group received treatment three times weekly
• Control group received sham (placebo) treatment
• Total treatment duration: 4 weeks

What Researchers Measured

The study evaluated:

• Wrinkle size and appearance
• Wrinkle depth and width
• Facial skin texture
• Facial appearance satisfaction
• Photographic assessments by specialists
• Optical imaging and wrinkle analysis software measurements

Key Findings

Researchers noted that photobiomodulation using red LED light has demonstrated benefits for:

• Facial rejuvenation
• Reduction of visible wrinkles
• Improvement in skin appearance
• Non-invasive anti-aging treatment support

The study was designed specifically to identify whether increasing treatment frequency could improve outcomes further.

Treatment Parameters

The LED mask delivered:

• 660 nm red light
• Approximately 21-minute sessions
• 8.02 J/cm² energy density
• 6.4 mW/cm² irradiance

https://pubmed.ncbi.nlm.nih.gov/36749255/