Effects of Diode Laser Photobiomodulation on Peri-Implant Inflammation and Stability in Orthodontic Mini-Implants

This randomized controlled trial evaluated whether diode laser photobiomodulation (PBM) could improve peri-implant health and reduce inflammation around orthodontic mini-implants. The study involved 30 orthodontic patients who received mini-implants on both sides of the maxilla, with one side treated using 650 nm diode laser irradiation (25 mW) and the other serving as a simulated-treatment control.

Key Findings

  • The PBM-treated group showed significantly lower plaque index, reduced sulcus bleeding, and shallower probing depth compared with the control group.
  • Patients had fewer cases of peri-implant mucositis (inflammation around mini-implants) in the laser-treated group.
  • IL-1β inflammatory marker levels in peri-implant fluid were consistently lower in the PBM group, suggesting reduced inflammation.
  • PBM improved peri-implant tissue health, but implant stability differences were not statistically significant.

Clinical Importance

These findings suggest that diode laser PBM may serve as a useful non-invasive adjunct therapy to reduce inflammation and improve healing around orthodontic mini-implants, potentially lowering complications and improving treatment comfort.

Limitations

  • Small sample size (30 patients)
  • Focused on short-term follow-up (1, 4, and 12 weeks)
  • More long-term and larger clinical studies are needed.

Conclusion

Diode laser photobiomodulation showed promising benefits in reducing peri-implant inflammation and improving tissue health, though its effect on implant stability remains unclear. It may be a valuable supportive therapy in orthodontic mini-implant care.

Simple takeaway: PBM may help reduce inflammation and improve healing around orthodontic mini-implants, but more long-term evidence is needed.

https://arxiv.org/abs/2511.11128

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