Photobiomodulation effects of pulsed-NIR laser (810 nm) and LED (808 ± 3 nm) with identical treatment regimen on burn wound healing: A quantitative label-free global proteomic approach
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This study compared the effects of pulsed near-infrared (NIR) laser (810 nm) and LED (808 ± 3 nm) photobiomodulation (PBM) on third-degree burn wound healing in rats using identical treatment settings. The goal was to determine whether laser and LED therapies had similar biological effects on tissue repair.
Researchers used global proteomic analysis, along with biochemical, molecular, histological, and immunohistochemical testing, to examine healing responses. Both laser and LED treatment groups showed similar activation of biological pathways involved in inflammation control, vascular repair, metabolism, cell signaling, and tissue regeneration.
The results showed reduced inflammatory markers such as TNF-α, IL-1β, IL-6, and COX-2, improved collagen and extracellular matrix formation, increased cell proliferation, enhanced wound contraction, and better tissue protection compared with untreated controls.
Key takeaway: Both 810 nm pulsed laser and 808 nm LED PBM were equally effective in promoting burn wound healing and reducing inflammation, suggesting LED therapy may be a practical non-invasive alternative to laser-based PBM for tissue repair.
https://www.sciencedirect.com/science/article/pii/S2666469021000099