Photobiomodulation Reduces Periocular Wrinkle Volume by 30%: A Randomized Controlled Trial (PMID: 36780572)

This randomized controlled split-face clinical trial investigated whether LED photobiomodulation (PBM) using red light (660 nm) and amber light (590 nm) could improve signs of facial aging, particularly periocular wrinkles (crow’s feet), in women with photoaged skin.

Key Findings

  • 137 women (ages 40–65) with facial photoaging participated.
  • Each side of the face received different wavelengths (red vs amber LED) using the same energy dose.
  • Treatment involved 10 PBM sessions over 4 weeks.
  • Both wavelengths significantly improved wrinkle appearance.
  • Periocular wrinkle volume decreased by ~31.6% with red light and ~29.9% with amber light.
  • Researchers also evaluated skin hydration, elasticity, and quality-of-life outcomes.
  • The treatment was non-invasive and well tolerated.

Clinical Takeaway

This study suggests that LED photobiomodulation may help reduce visible crow’s feet and support facial skin rejuvenation, with both red and amber wavelengths showing measurable wrinkle-reduction benefits. It supports PBM as a promising non-invasive anti-aging skin therapy.

https://pubmed.ncbi.nlm.nih.gov/36780572/

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