Photobiomodulation Therapy for Chemotherapy-Induced Peripheral Neuropathy: Potential Mechanisms and Clinical Perspectives (2020)

This review examined the potential role of photobiomodulation (PBM)/low-level laser therapy in managing chemotherapy-induced peripheral neuropathy (CIPN), a common side effect of cancer treatment that can cause pain, numbness, tingling, and impaired function.

Key findings:

• Pain relief: PBM showed potential to reduce neuropathic pain and discomfort associated with CIPN.
• Nerve protection & regeneration: Light therapy may support nerve repair, regeneration, and improved neuronal function.
• Reduced inflammation & oxidative stress: PBM may help modulate inflammatory pathways and reduce oxidative damage involved in nerve injury.
• Improved circulation & cellular metabolism: Benefits may be linked to enhanced mitochondrial activity, ATP production, and improved blood flow, supporting tissue recovery.
• Functional improvement: Early evidence suggested possible improvements in sensation, mobility, and overall quality of life in affected patients.

Conclusion:

The review suggests that photobiomodulation may be a promising non-invasive supportive therapy for chemotherapy-induced peripheral neuropathy, mainly through neuroprotective, anti-inflammatory, and regenerative effects. However, the authors emphasized that clinical evidence is still limited, and larger standardized trials are needed to confirm efficacy, safety, and ideal treatment parameters.

https://pubmed.ncbi.nlm.nih.gov/32204620/