Photobiomodulation Therapy in Skin Wound Healing, Tissue Remodeling, and Regeneration (

This review examines the role of photobiomodulation therapy (PBMT) in skin wound healing, tissue remodeling, and regeneration. PBMT uses low-intensity red or near-infrared light to stimulate biological processes that help accelerate tissue repair and reduce inflammation without causing thermal damage.

The article explains that PBMT works mainly through mitochondrial stimulation, particularly by activating cytochrome c oxidase, which increases ATP production, regulates reactive oxygen species (ROS), and promotes signaling pathways involved in cell proliferation, collagen synthesis, angiogenesis, and tissue regeneration. These effects can improve wound closure, reduce inflammation, and enhance tissue remodeling.

The review highlights PBMT’s therapeutic potential in chronic wounds, diabetic ulcers, burns, surgical wounds, and skin tissue repair. It also discusses how PBMT may improve blood flow, reduce oxidative stress, and support extracellular matrix formation. However, treatment outcomes depend heavily on factors such as wavelength, energy dose, exposure duration, and treatment frequency.

Key takeaway: PBMT is a promising non-invasive therapy for wound healing and tissue regeneration, particularly in chronic and difficult-to-heal wounds, but standardized clinical protocols and further studies are needed to optimize treatment effectiveness.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11503318/