Photobiomodulation Therapy in the Treatment of Neurological Disorders: Mechanisms and Clinical Perspectives (2023)

This review explored how photobiomodulation (PBM)/low-level light therapy may be used in neurological disorders, including conditions affecting brain function, neuroinflammation, and neurodegeneration.

Key findings:

• Neuroprotection: PBM may help protect neurons from oxidative stress and cellular damage.
• Improved mitochondrial function: Therapy appears to enhance ATP production and cellular energy metabolism, which supports brain cell survival and function.
• Reduced inflammation: PBM may reduce neuroinflammation, a key factor in many neurological diseases.
• Better blood flow & tissue repair: Light therapy may improve cerebral circulation and aid neural recovery.
• Potential clinical uses: Research suggests possible benefits in conditions such as stroke recovery, traumatic brain injury, cognitive impairment, Parkinson’s disease, and mood-related disorders, though evidence varies by condition.

Conclusion:

The review suggests that photobiomodulation is a promising non-invasive adjunct therapy for neurological disorders, mainly through mitochondrial stimulation, anti-inflammatory effects, neuroprotection, and improved cerebral blood flow. However, the authors emphasized that clinical evidence is still evolving, and larger standardized trials are needed to confirm safety, efficacy, and ideal treatment parameters.

https://pubmed.ncbi.nlm.nih.gov/37843594/