Photobiomodulation Therapy in Tissue Repair and Regeneration: Current Insights and Clinical Applications

This review explores the role of photobiomodulation therapy (PBMT) in tissue repair, wound healing, and regenerative medicine. PBMT uses low-level red or near-infrared light to stimulate cellular responses that promote healing, reduce inflammation, and support tissue regeneration without causing thermal injury.

The article explains that PBMT primarily works by targeting mitochondrial activity, especially cytochrome c oxidase, which increases ATP production, regulates reactive oxygen species (ROS), and activates signaling pathways involved in cell proliferation, collagen synthesis, angiogenesis, and tissue remodeling. These effects can improve circulation, accelerate wound closure, and enhance tissue repair.

The review highlights PBMT’s potential applications in chronic wounds, diabetic ulcers, musculoskeletal injuries, nerve regeneration, skin repair, and inflammatory conditions. It also emphasizes that treatment outcomes depend heavily on proper parameters such as wavelength, dosage, exposure time, and treatment frequency.

Key takeaway: PBMT shows strong promise as a non-invasive supportive therapy for tissue healing and regeneration, but standardized treatment protocols and further clinical trials are needed to confirm long-term effectiveness and broader clinical use.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11671386/