Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders: A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials (2021)
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This 2021 systematic review and meta-analysis evaluated the effectiveness of photobiomodulation therapy (PBMT), also known as low-level laser therapy (LLLT), in treating temporomandibular disorders (TMDs), which commonly cause jaw pain, limited jaw movement, and reduced quality of life. The review analyzed 44 randomized controlled trials, with 32 studies included in the meta-analysis.
Researchers examined whether PBMT delivered through lasers or LEDs could improve pain, jaw function, psychological symptoms, and quality of life compared with placebo treatments and other therapeutic approaches.
Key findings include:
- Photobiomodulation therapy was associated with significant reductions in pain intensity, particularly in the short term.
- PBMT improved jaw function and masticatory performance, helping patients achieve better functional outcomes.
- The therapy showed potential benefits for quality of life, especially when used alone or combined with other treatment modalities.
- Results regarding the most effective treatment parameters, including dosage and wavelength, were inconsistent across studies.
- The authors highlighted the role of PBMT in reducing oxidative stress and inflammation, mechanisms believed to contribute to symptom relief in TMD patients.
Conclusion
The review concluded that the majority of available evidence supports the use of photobiomodulation therapy for improving chronic pain, jaw function, and quality of life in patients with temporomandibular disorders. However, variability in treatment protocols and study designs indicates that further high-quality research is needed to establish standardized clinical guidelines.
Key Takeaway:
Photobiomodulation therapy appears to be a promising non-invasive treatment for temporomandibular disorders, with evidence suggesting meaningful improvements in pain relief, jaw function, and overall quality of life.
https://pubmed.ncbi.nlm.nih.gov/34202292/