The Efficacy of Laser Therapy in Melasma Treatment: A Systematic Review and Meta-Analysis

This 2025 systematic review and meta-analysis evaluated how effective laser therapy is for treating melasma, a common skin hyperpigmentation condition that often affects the face. Researchers reviewed 16 randomized controlled trials (RCTs) involving 471 patients, analyzing changes in Melasma Area and Severity Index (MASI) scores before and after treatment.

Key Findings

  • Laser therapy generally improved melasma severity, with most studies showing reduced MASI scores after treatment.
  • The most commonly studied device was the 1064-nm Q-switched Nd:YAG laser.
  • Treatment protocols varied:
    • 2–12 sessions
    • Intervals of 1–4 weeks
    • Follow-up periods of 2–6 months
  • Overall, the pooled data suggested laser therapy can be an effective treatment option, but outcomes varied depending on laser type, treatment frequency, and recurrence risk.

Clinical takeaway

This review supports that laser-based therapies may help reduce melasma pigmentation, especially certain Nd:YAG-based approaches, but melasma is known for recurrence, so long-term management and individualized treatment remain important.

https://pubmed.ncbi.nlm.nih.gov/41378674/

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